Use in Cancer. Arsenic trioxide is approved to be used with tretinoin to treat: Acute promyelocytic leukemia (APL) in patients whose cancer has a certain type of chromosome mutation that affects the PML gene and RARA gene. It is used: In adults with newly diagnosed APL that is low risk.

chemotherapy during treatment of the leukocyte activation syndrome due to arsenic trioxide. Post--marketing experience suggests that a similar syndrome may

Calculate the molar mass of Arsenic Trioxide in grams per mole or search for a chemical formula or substance. Buy online ARSENIC TRIOXIDE 99% AR-100 gm A-01141-100 gm 1327-53-3 at best price in India on Biomall. Request quote for laboratory supplies, chemicals Oct 5, 2015 Arsenic(III) oxide react with sodium hydroxide to produce sodium metaarsenite and water. Chemical reaction. Balancing chemical equations. Sep 10, 2015 It's molecular geometry is trigonal pyramidal, not trigonal planar. Explanation: Check out this answer on the molecular geometry of arsenic The Arsenic atom goes in the center of the Lewis structure since it is the least electronegative atom.

Blood 2006;;107(9):346973.- 2021-04-07 2021-03-17 Arsenic trioxide has been investigated in 77 newly diagnosed patients with low to intermediate risk APL, in a controlled, randomized, non-inferiority Phase 3 clinical study comparing the efficacy and safety of arsenic trioxide combined with all-trans-retinoic acid (ATRA) with those of ATRA+chemotherapy (eg, idarubicin and mitoxantrone) (Study APL0406). /day for 14 days and the dose of arsenic trioxide was reduced to 0.08 mg/kg/day. In particular, the compulsory use of prednisone (or prednisolone) as prophylactic therapy and the delayed introduction of arsenic trioxide on day 9 of the induction therapy was expected to almost completely eliminate the severest form of APL differentiation syndrome. Colloidal gadolinium arsenite has been developed as an arsenic trioxide nanoparticle prodrug (ATONP) by our group in the past five years, and it has illustrated to be highly promising for cancer therapy. Here, we systemically synthesized arsenites of all the rare-earth elements, characterized their element-d We examined whether combining all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) might be an alternative to ATRA plus chemotherapy in untreated acute promyelocytic leukemia (APL).Twenty-five low-risk patients (white blood cell [WBC] count less than 10 × 10 9 /L [10 000/μL]) received ATRA (45 mg/m 2 daily) and ATO (0.15 mg/kg daily, beginning day 10 of ATRA), and in complete remission Arsenic Trioxide may be temporarily discontinued in the presence of o Differentiation syndrome (Table 1) o Hepatotoxicity (Table 1) o QT prolongation on ECG (see Arsenic Trioxide and QT prolongation below) Arsenic Trioxide will need to be discontinued permanently in the event of cardiac arrhythmias or severe neurological toxicity. Consolidation therapy of arsenic trioxide alternated with chemotherapy achieves remarkable efficacy in newly diagnosed acute promyelocytic leukemia Cheng-cheng Liu,1-3,* Hua Wang,1-3,* Wei-da Wang,1-3 Meng-yuan Zhu,1-3 Qi-rong Geng,1-3 Yue Lu1-31Department of Hematological Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China; 2State Key Laboratory of Oncology Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL. Pharmacokinetics: 1.

This is not surprising, since the combination of ATRA plus arsenic trioxide without chemotherapy has a 98% 5-year event-free survival in low- risk patients and

Injection: 12 mg/6 mL (2 mg/mL) arsenic trioxide in single-dose vial. (3) CONTRAINDICATIONS Hypersensitivity to arsenic.

Introduction: Arsenic trioxide is effective and approved for treatment of relapsed or refractory acute promyelocytic leukemia (APL) cases resistant to all-trans retinoic acid (ATRA), but its effect on new cases of APL is not clear. Materials and methods: We studied 111 patients with APL.

N Engl J Med 1998;339(19):1341-48. 2. Estey E, Garcia-Manero G, Ferrajoli A, et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia.

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As a medication, it is used to treat a type of cancer known as acute promyelocytic leukemia. For this use it is given by injection into a vein. INTRODUCTION Small cell lung cancer (SCLC) carries high mortality despite standard chemotherapy. Arsenic trioxide (ATO) has demonstrated clinical efficacy in leukemia and in vitro activity in various solid tumors. This study was conducted to determine the in vitro and in vivo combination effects of ATO and chemotherapy in SCLC.

MATERIALS AND METHODS The in vitro model consisted of 5 SCLC cell CONCLUSIONS: Arsenic trioxide is effective as first-line treatment for APL. Results of arsenic trioxide combination therapy with chemotherapy/ATRA requires further study. PMID: 16227315 [Indexed for MEDLINE] MeSH terms.
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ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) Consolidation is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + arsenic trioxide work? At diagnosis, APL cells are "trapped" in an immature phase of maturation, do not function normally, and can suppress the growth of good cells in the bone marrow.

Induction of remission and consolidation in adult patients with. • newly diagnosed low-to-intermediate risk acute This is not surprising, since the combination of ATRA plus arsenic trioxide without chemotherapy has a 98% 5-year event-free survival in low- risk patients and Dec 5, 2016 SAN DIEGO – All-trans retinoic acid (ATRA) plus arsenic trioxide with or without chemotherapy induces high remission rates among patients Arsenic Trioxide (Trisenox) is given intravenously (IV) to treat cancer. Find side effects, allergic reactions, and food and drug interactions. Mar 1, 2021 Arsenic trioxide injection is used together with another medicine (eg, tretinoin) to treat newly-diagnosed low-risk acute promyelocytic leukemia Dec 31, 2000 The injectable form of arsenic trioxide (Trisenox) was recently md, investigator in the Developmental Chemotherapy Service atMemorial Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia.

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Combined effect of all-trans retinoic acid and arsenic trioxide in acute target gene that mediates granulocytic differentiation and resistance to chemotherapy.

Injection: 12 mg/6 mL (2 mg/mL) arsenic trioxide in single-dose vial. (3) CONTRAINDICATIONS Hypersensitivity to arsenic. (4) WARNINGS AND PRECAUTIONS • Hepatotoxicity: Elevated aspartate aminotransferase (AST), alkaline phosphatase and serum bilirubin have occurred in patients with newly-diagnosed low-risk APL treated with TRISENOX The therapeutic advantage of the association of ATRA + Arsenic Trioxide is more favorable and manageable as compared to ATRA + chemotherapy. Nevertheless, at present, there is not enough information on the incidence of long-term side effects.

Description: Arsenic trioxide, an antineoplastic agent, induces apoptosis by causing morphological changes and DNA fragmentation in acute promyelocytic leukemia (APL) cells.It also damages and degrades promyelocytic leukemia (PML)-retinoic acid receptor (RAR)-α fusion gene, a characteristic of APL. Pharmacokinetics:

Arsenic trioxide has been investigated in 77 newly diagnosed patients with low to intermediate risk APL, in a controlled, randomized, non-inferiority Phase 3 clinical study comparing the efficacy and safety of arsenic trioxide combined with all-trans-retinoic acid (ATRA) with those of ATRA+chemotherapy (eg, idarubicin and mitoxantrone) (Study APL0406). Efficacy of intratumoral chemotherapy using arsenic trioxide (As2O3) sustained release tablets for the treatment of neurogliocytoma in nude mice. Eur Rev Med Pharmacol Sci Year: 2014 Vol. 18 - N. 17 . Pages: 2453-2459 Arsenic trioxide was initially approved in 2000 as a treatment for patients with APL who are refractory or have relapsed on retinoid and anthracycline chemotherapy. The agent was approved as a frontline therapy for patients with low- and intermediate-risk APL in the European Union in November 2016. /day for 14 days and the dose of arsenic trioxide was reduced to 0.08 mg/kg/day. In particular, the compulsory use of prednisone (or prednisolone) as prophylactic therapy and the delayed introduction of arsenic trioxide on day 9 of the induction therapy was expected to almost completely eliminate the severest form of APL differentiation syndrome.

chemotherapy, 43% for chemotherapy and BMT and 82% for chemotherapy plus arsenic trioxide (p = 0.0004). In a randomized controlled trial of arsenic trioxide monotherapy vs. arsenic trioxide plus ATRA therapy in 20 patients with relapsed APL, Raffoux and colleagues6 demonstrated a CR2 rate of 80% after one ATRA (Tretinoin) + Arsenic Trioxide (Trisenox®) is a Chemotherapy Regimen for Acute Promyelocytic Leukemia (APL) How does ATRA + Arsenic Trioxide work? At diagnosis, APL cells are "trapped" in an immature phase of maturation, do not function normally, and can suppress the growth of good cells in the bone marrow. Arsenic trioxide, a cancer chemo drug hampers fibrotic liver regeneration by interrupting oxidative stress rekindling and stellate cell rejuvenation J Cell Physiol . 2020 Feb;235(2):1222-1234. doi: 10.1002/jcp.29037.